Hydrochloric Acid → Furaneol

HRID 36058

반응식

HRID 36058 반응식
[OH-].[Na+].[CH3:3][C:4]1[O:8][C:7]([C:9](OCC)=O)=[C:6]([OH:14])[C:5]=1[OH:15].CBr.Cl>O>[CH3:3][CH:4]1[C:5](=[O:15])[C:6]([OH:14])=[C:7]([CH3:9])[O:8]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6323Methyl BromideHCID 14798Sodium HydroxideHCID 54719681Ethyl 5-methyl-3,4-dihydroxy-2-furoate

생성물 1

HCID 19309Furaneol수율 81.4%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A solution of 48 g of sodium hydroxide and 37.2 g of ethyl 5-methyl-3,4-dihydroxy-2-furoate of 98.4% purity in 225 ml of water was allowed to stand at room temperature for 40 hours. The mixture was diluted with 200 g of water and 22.8 g of gaseous methyl bromide was added with stirring over a period of one hour at room temperature followed by an additional stirring period of two hours. The pH of the solution was adjusted to 5 by the addition of concentrated hydrochloric acid solution. Extraction with methyl t-butyl ether yielded 21.5 9 of 2,5-dimethyl-4-hydroxy-3[2H] furanone of 95.3% purity (molar yield 81.4%).

후처리

  1. additionwas added
  2. stirringan additional stirring period of two hours
  3. extractionExtraction with methyl t-butyl ether

출처 및 근거

ORD 기록
ord-0e774a8b21704e8588d5eb566a51ada1
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05412121

연결된 노트

불러오는 중…