Hydrochloric Acid → 1-Ethyl-5-nitro-indoline

HRID 361395

반응식

HRID 361395 반응식
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=2)[CH2:6][CH2:5]1)(=O)[CH3:2].Cl>>[CH2:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=2)[CH2:6][CH2:5]1)[CH3:2]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 36566Ethanone, 1-(2,3-dihydro-5-nitro-1H-indol-1-yl)-

생성물 1

HCID 234991451-Ethyl-5-nitro-indoline수율 109.4%

반응 조건

온도
50 °C

실험 절차

1-Acetyl-5-nitro-indoline (1.00 g, 4.85 mmol) was added to borane-THF complex 1M, 10 mL, 10 mmol). The mixture was heated at reflux for 4 h. With ice-water bath cooling, the mixture was slowly reated with 6N HCl (4 mL). Then the mixture was heated at 50° C. for 1 h. The organic solvent was evaporated off and the resulting suspension was filtered to give an orange solid (1.02 g) which was washed with water: mp 97°-98° C.

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 4 h
  3. temperatureWith ice-water bath cooling
  4. customThe organic solvent was evaporated off
  5. filtrationthe resulting suspension was filtered

출처 및 근거

ORD 기록
ord-cae08d09cb174c56a3c433fba5933db8
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05866579

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