5-Aminouracil → 2499-96-9

HRID 361406

반응식

HRID 361406 반응식
[NH2:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=1.[CH:10](=O)/[CH:11]=[CH:12]/[CH3:13]>Cl>[O:8]=[C:5]1[NH:6][C:7]2[CH:10]=[CH:11][C:12]([CH3:13])=[N:1][C:2]=2[C:3](=[O:9])[NH:4]1

참가 물질

4

반응물 2

HCID 136115-AminouracilHCID 447466Crotonaldehyde

생성물 1

HCID 2732402499-96-9수율 248.1%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

20 g of 5-aminouracil (40 mmol), 80 ml of 20% HCl and 4 ml of crotonaldehyde (50 mmol) were heated together under reflux for 1 hour. The solution was evaporated to dryness under rotarary evaporation. Water was added to the residue so as to make the mixture just stirrable and then it was triturated with ammonium hydroxide with strong stirring until the pH increased to 10-11. Stirring was continued for another 10 minutes. The precipitate was filtered and was washed with minimal methanol and then chloroform and dried to give 17.58 g (63%) of 1.

후처리

  1. temperatureunder reflux for 1 hour
  2. customThe solution was evaporated to dryness under rotarary evaporation
  3. additionWater was added to the residue so as
  4. customit was triturated with ammonium hydroxide
  5. temperatureincreased to 10-11
  6. stirringStirring
  7. filtrationThe precipitate was filtered
  8. washwas washed with minimal methanol
  9. dry with materialchloroform and dried

출처 및 근거

ORD 기록
ord-c564fdbb6d5044b58a8ed55a50be5794
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05866580

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