Azobisisobutyronitrile → 3-Phenyl-2-chloro-6-bromomethylpyridine
반응식
[C:1]1([C:7]2[C:8]([Cl:14])=[N:9][C:10]([CH3:13])=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1C(=O)N([Br:22])C(=O)C1.CC(N=NC(C#N)(C)C)(C#N)C>C(Cl)(Cl)(Cl)Cl>[C:1]1([C:7]2[C:8]([Cl:14])=[N:9][C:10]([CH2:13][Br:22])=[CH:11][CH:12]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1참가 물질
5
실험 절차
A solution of 3-Phenyl-2-chloro-6-methylpyridine (0.094 g, 0.462 mmol), NBS (0.086 g, 0.485 mmol) and AIBN (0.008 g, 0.046mmol) in CCl4 (3 mL) were heated at reflux for 2 hours. The solvent was evaporated and the residue chromatographed (Silica gel, 100% CH2Cl2 to afford the title compound.
후처리
- temperatureat reflux for 2 hours
- customThe solvent was evaporated
- customthe residue chromatographed (Silica gel, 100% CH2Cl2
출처 및 근거
- ORD 기록
- ord-6d7d8198179a4f568c3b52dbfa301801
- 출처 데이터셋
- uspto-grants-1999_02
- 특허 번호
- US05872136
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