1,2-Dichloroethane → 3-Ethyl-1-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene

반응식

[CH2:1]([C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1)[CH3:2].[CH:10]1[C:15](O)=[CH:14][CH:13]=[CH:12][C:11]=1[CH3:17].[CH2:18](Cl)CCl>>[CH2:1]([C:3]1[CH:4]=[C:5]([OH:9])[C:6]2[C:11]([CH3:10])([CH3:17])[CH2:12][CH2:13][C:14]([CH3:15])([CH3:18])[C:7]=2[CH:8]=1)[CH3:2]

참가 물질

반응물 3

HCID 111,2-Dichloroethane

HCID 342M-Cresol

HCID 121013-Ethylphenol

생성물 1

HCID 190951933-Ethyl-1-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene수율 66%

실험 절차

Employing procedures and materials similar to those described in Example 1, except that 3-ethylphenol was substituted for m-cresol, and the reaction was carried out in the presence of ethylene dichloride as solvent, there was obtained the desired product, 3-ethyl-1-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene 66% theor., GLC purity 99%+, exhibiting the expected spectral data.

출처 및 근거

ORD 기록: ord-b3a280ef250a44ee8ab17496f4e37be6
출처 데이터셋: uspto-grants-1986_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04605778

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