Water → 1-Bromoethyl ethyl carbonate

HRID 364870

반응식

HRID 364870 반응식
[Br-:1].[Li+].[C:3](=[O:11])([O:7][CH:8](Cl)[CH3:9])[O:4][CH2:5][CH3:6].O>[Br-].C([N+](C)(C)C)CCCCCCCCCCCCCCC.ClCCl>[C:3](=[O:11])([O:7][CH:8]([Br:1])[CH3:9])[O:4][CH2:5][CH3:6]

참가 물질

6

반응물 3

HCID 962WaterHCID 82050Lithium BromideHCID 162095Carbonic acid, 1-chloroethyl ethyl ester

생성물 1

HCID 30215501-Bromoethyl ethyl carbonate수율 76%

시약·촉매·용매 2

HCID 5974Hexadecyltrimethylammonium Bromide촉매HCID 6344Dichloromethane용매

반응 조건

온도
35 °C

실험 절차

A mixture of lithium bromide (43 g, 0.5 m), ethyl alphachloroethyl carbonate (15.3 g, 0.1 m); water (100 ml), dichloromethane (100 ml) and cetyl trimethyl ammonium bromide (1.5 g) was stirred at ambient temperature for 24 hours. The aqueous layer was removed and replaced by a fresh solution of lithium bromide (26 g, 0.3 m) in water (40 ml) containing cetyl trimethyl ammonium bromide (1 g). After stirring for a further 24 hours during which time the temperature was raised to 35° C., the organic layer was separated, dried and vacuum distilled to afford after repeated fractionation the new compound, ethyl alpha-bromoethyl carbonate (15.0 g, 76% yield) having a boiling point of 90°-92° C. at 35 mms of mercury pressure.

후처리

  1. customThe aqueous layer was removed
  2. additioncontaining cetyl trimethyl ammonium bromide (1 g)
  3. customthe organic layer was separated
  4. customdried
  5. distillationvacuum distilled
  6. customto afford

출처 및 근거

ORD 기록
ord-75c976b030f141568083f517c6320f1f
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04606865

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