4-Fluoroaniline → 2-(4'Fluorophenyl) aminocyclohex-1-ene-1-carbonitrile

반응식

[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.O=[C:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH:11]1[C:16]#[N:17].[Cl-].[Ca+2].[Cl-]>>[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:10]2[CH2:15][CH2:14][CH2:13][CH2:12][C:11]=2[C:16]#[N:17])=[CH:4][CH:3]=1

참가 물질

반응물 3

HCID 97314-Fluoroaniline

HCID 2202972-Oxocyclohexanecarbonitrile

HCID 5284359Calcium Chloride

생성물 1

HCID 702554742-(4'Fluorophenyl) aminocyclohex-1-ene-1-carbonitrile

실험 절차

4-Fluoro-aniline (1.11 g, 10.0 mmol), cyano-ketone (Example 32) (1.25 g, 10.2 mmol), calcium chloride (1.5 g, 13.5 mmol) and T.H.F. (20 ml) were heated under reflux for 17 hours. After cooling, the mixture was filtered and the solvent evaporated. Kugelrohr distillation (135° C., 0.08 mmHg) gave the product as a pale yellow powder.