Acetophenone → Ccris 2231

HRID 36738

반응식

HRID 36738 반응식
[OH-].[Na+].[CH:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][CH:5]=1.[C:13]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)(=O)[CH3:14]>CCO.O>[CH3:11][O:10][C:7]1[CH:8]=[CH:9][C:4]([C:3](=[O:12])[CH:14]=[CH:13][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:5][CH:6]=1

참가 물질

6

반응물 3

HCID 7410AcetophenoneHCID 14798Sodium HydroxideHCID 312444-Methoxybenzaldehyde

생성물 1

HCID 92853Ccris 2231수율 56%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Step A Add 10% aqueous NaOH (38 mL) to a solution of p-anisaldehyde (25 mL, 0.206 mol) and acetophenone (23.97 mL, 0.206 mol) in EtOH (500 mL). Stir the mixture at room temperature over night. Dilute the mixture with water and extract with ether. Combine the ethereal extracts, wash with water and brine, dry over Na2SO4 and concentrate to a solid. Recrystallize the solid from ether/hexanes to provide 27.51 g (56%) of 4'-methoxychalcone, mp 72°-74° C.

후처리

  1. extractionextract with ether
  2. washwash with water and brine
  3. dry with materialdry over Na2SO4
  4. concentrationconcentrate to a solid
  5. customRecrystallize the solid from ether/hexanes

출처 및 근거

ORD 기록
ord-8a78853258fc48d2bcf415d810e7317d
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05416118

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