Pyridine-2-carbonitrile → HCID 18460108, 화합물

HRID 367786

반응식

HRID 367786 반응식
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)#[N:2].[NH2:9][C:10]1[S:11][C:12]([CH3:20])=[CH:13][C:14]=1[C:15](OCC)=O.O=P(Cl)(Cl)[Cl:23]>>[Cl:23][C:15]1[C:14]2[CH:13]=[C:12]([CH3:20])[S:11][C:10]=2[N:9]=[C:1]([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=2)[N:2]=1

참가 물질

4

반응물 3

HCID 7522Pyridine-2-carbonitrileHCID 24813Phosphorus oxychlorideHCID 4062885Ethyl 2-Amino-5-methylthiophene-3-carboxylate

생성물 1

HCID 18460108HCID 18460108, 화합물

실험 절차

With the procedure of Example 477, the reaction of 2-cyanopyridine and 2-amino-5-methyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-(pyridin-2-yl)-6-methyl-thieno-[2,3-d]-pyrimidine

출처 및 근거

ORD 기록
ord-5adba04b96d0439fbb670c3571682000
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06133271

연결된 노트

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