Phenol → Methyl-4-(trans-3-decenyloxy)-benzoate

HRID 369533

반응식

HRID 369533 반응식
C1(O)C=CC=CC=1.C(O)C/C=C/CCCCCC.CCOC(/N=N/C(OCC)=O)=O.[CH3:31][O:32][C:33](=[O:59])[C:34]1[CH:39]=[CH:38][C:37]([O:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50]CCCCCCCC)=[CH:36][CH:35]=1>CCOCC>[CH3:31][O:32][C:33](=[O:59])[C:34]1[CH:39]=[CH:38][C:37]([O:40][CH2:41][CH2:42]/[CH:43]=[CH:44]/[CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH3:50])=[CH:36][CH:35]=1

참가 물질

6

반응물 4

HCID 996PhenolHCID 4189536Methyl 4-(octadecyloxy)benzoateHCID 53524933-Decen-1-ol, (3E)-HCID 5462977Diethyl azodicarboxylate

생성물 1

HCID 18521096Methyl-4-(trans-3-decenyloxy)-benzoate수율 85%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Ester 34 (500 mg, 3.29 mmol), 3-decenol 26h (514 mg, 3.29 mmol), TPP (992 mg, 3.78 mmol), DEAD (658 mg, 3.78 mmol), and 33 ml ether were reacted according to the procedure for compound 35a. The crude product was purified via flash chromatography over silica gel with gradual elutions from 95/5-90/10 (v/v, Hex/EtOAc). Evaporation of solvent yielded 810 mg (85%) of colorless liquid which was not quite pure. The product was used without further purification.

후처리

  1. customThe crude product was purified via flash chromatography over silica gel with gradual elutions from 95/5-90/10 (v/v, Hex/EtOAc)
  2. customEvaporation of solvent

출처 및 근거

ORD 기록
ord-6fce36808b4841f78ea78c017314a9bc
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06139771

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