Hydrochloric Acid → 2-Methylbenzenesulfonic acid

HRID 370007노트

반응식

HRID 370007 반응식
N#[C-].N[C:4]1[CH:12]=[CH:11][C:7]([C:8](N)=N)=[CH:6][CH:5]=1.Cl.[S:14](=O)(=[O:17])([OH:16])[OH:15].B(F)(F)F.CCOCC>O.C(O)(C)C.O1CCCC1.O1CCOCC1.C(O)C.CO>[C:7]1([CH3:8])[C:6]([S:14]([OH:17])(=[O:16])=[O:15])=[CH:5][CH:4]=[CH:12][CH:11]=1

참가 물질

12

반응물 5

HCID 313Hydrochloric AcidHCID 1118Sulfuric AcidHCID 1725p-AminobenzamidineHCID 5975CyanideHCID 8000Boron trifluoride etherate

생성물 1

HCID 69252-Methylbenzenesulfonic acid

시약·촉매·용매 6

HCID 702Ethanol용매HCID 887Methanol용매HCID 962Water용매2회HCID 3776Isopropanol용매2회HCID 8028Tetrahydrofuran용매2회HCID 312751,4-Dioxane용매

실험 절차

The reaction of a substituted benzaldehyde of the formula II, an isonitrile of the formula RNC and a 4-aminobenzamidine of the formula III is advantageously carried out in a solvent (e.g. methanol, isopropanol, ethanol, dioxane, or tetrahydrofuran), or in a solvent mixture (e.g. tetrahydrofuran and water or isopropanol and water), advantageously by using an inorganic acid (e.g. hydrochloric acid, sulphuric acid or boron trifluoride etherate), or an organic acid (e.g. toluenesulphonic acid), or in acidic ion exchanger (e.g. Amberlyst K10) as catalyst, at a temperature between 0° C. and 100° C., giving compounds of the formula I. The reaction of a substituted aldehyde of the formula II, of an isonitrile of the formula R1NC and 4-aminobenzonitrile under similar reaction conditions leads to compounds of the formula IV in which Q is hydrogen.

출처 및 근거

ORD 기록
ord-ad53b657205646afaa67ccde8672ba4f
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06140353

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