Boron trifluoride etherate → 2,3,5,6-Tetrafluorophenyl trifluoroacetate

HRID 37028

반응식

HRID 37028 반응식
F[C:2]([F:13])(F)[C:3]([O:5][C:6](=[O:11])[C:7]([F:10])([F:9])[F:8])=O.[F:14][C:15]1[C:20]([F:21])=CC(F)=[C:17]([F:23])[C:16]=1O.B(F)(F)F.CCOCC>>[F:10][C:7]([F:8])([F:9])[C:6]([O:5][C:3]1[C:2]([F:13])=[C:17]([F:23])[CH:16]=[C:15]([F:14])[C:20]=1[F:21])=[O:11]

참가 물질

4

반응물 3

HCID 8000Boron trifluoride etherateHCID 9845Trifluoroacetic anhydrideHCID 698582,3,5,6-Tetrafluorophenol

생성물 1

HCID 153342582,3,5,6-Tetrafluorophenyl trifluoroacetate수율 75%

실험 절차

Trifluoroacetic anhydride (28 mL, 0.2 mol) was added dropwise with stirring to 27.1 g (0,163 mol) of 2,3,5,6tetrafluorophenol. Boron trifluoride etherate (0.2 mL) was added and the mixture was refluxed overnight. The residual solution was distilled at atmospheric pressure to remove trifluoroacetic anhydride and trifluoroacetic acid. The desired product 18 (32.2 g; 75% yield) was collected at 45° C. (18mm) as a colorless liquid:

후처리

  1. temperaturethe mixture was refluxed overnight
  2. distillationThe residual solution was distilled at atmospheric pressure
  3. customto remove trifluoroacetic anhydride and trifluoroacetic acid

출처 및 근거

ORD 기록
ord-0f9b25f93fa74c2990bd28e8b3c03f57
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05419966

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