Water → 2-(2-Bromoethyl)naphthalene

HRID 370646

반응식

HRID 370646 반응식
P(Br)(Br)[Br:2].[CH:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][C:6]=1[CH2:15][CH2:16]O.N1C=CC=CC=1.O>C(Cl)(Cl)Cl>[Br:2][CH2:16][CH2:15][C:6]1[CH:7]=[CH:8][C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:5]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 1049PyridineHCID 24614Phosphorus tribromideHCID 738772-Naphthaleneethanol

생성물 1

HCID 2282702-(2-Bromoethyl)naphthalene

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

A solution of phosphorus tribromide (3.52 g, 0.013 mol) in chloroform (6.25 ml) was added dropwise at -10° to a stirred solution of 2-naphthalene-ethanol (4.3 g, 0.025 mol) in chloroform (20 ml), containing dry pyridine (0.13 ml, 0.0016 mol). Following the addition, the mixture was stirred at -10° for 2 h, and was then stood at ambient temperature overnight. Next day, the reaction mixture was poured into water (62.5 ml) and the organic layer was separated. The aqueous solution was then extracted with chloroform (3×6.25 ml), and the organic layer and chloroform extracts were combined and washed with sodium hydroxide solution (62.5 ml, 2M), and with water (62.5 ml). The chloroform solution was dried (MgSO4), and the chloroform was then evaporated under reduced pressure to afford 2-(2-bromoethyl)naphthalene which was used without further purification.

후처리

  1. additionthe addition
  2. waitwas then stood at ambient temperature overnight
  3. customthe organic layer was separated
  4. extractionThe aqueous solution was then extracted with chloroform (3×6.25 ml)
  5. washwashed with sodium hydroxide solution (62.5 ml, 2M)
  6. dry with materialThe chloroform solution was dried (MgSO4)
  7. customthe chloroform was then evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-e3d7de8d34b647abb7333a2253c428b9
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04528195

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