Hydrochloric Acid → 9-(2-Deoxy-2-fluoro-beta-D-ribofuranosyl)adenine hydrochloride

HRID 37087

반응식

HRID 37087 반응식
[F:1][C@@H:2]1[C@H:6]([OH:7])[C@@H:5]([CH2:8][OH:9])[O:4][C@H:3]1[N:10]1[CH:18]=[N:17][C:16]2[C:11]1=[N:12][CH:13]=[N:14][C:15]=2[NH2:19].C(O)(C)C.[ClH:24]>CO.O>[ClH:24].[F:1][C@@H:2]1[C@H:6]([OH:7])[C@@H:5]([CH2:8][OH:9])[O:4][C@H:3]1[N:10]1[CH:18]=[N:17][C:16]2[C:11]1=[N:12][CH:13]=[N:14][C:15]=2[NH2:19]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 1002532'-Fluoro-2'-deoxyadenosine

생성물 1

HCID 677407569-(2-Deoxy-2-fluoro-beta-D-ribofuranosyl)adenine hydrochloride

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of 9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)adenine (500 mg. 1.86 mmol) in MeOH (40 ml) and water (10 ml) was added a solution of isopropanol (15 ml) previously saturated with HCl gas. The solution was evaporated under vacuum at room temperature, and triturated with EtOH (25 ml) to afford the title compound as a white solid.

후처리

  1. customThe solution was evaporated under vacuum at room temperature
  2. customtriturated with EtOH (25 ml)

출처 및 근거

ORD 기록
ord-6f3bdcf96f5c441380f7fe1672130045
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05420115

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