Hydrochloric Acid → 4-(3,5-Dichloro-pyridin-2-yloxy)-phenol

HRID 371035노트

반응식

HRID 371035 반응식
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Cl:9])=[CH:4][N:3]=1.[C:10]1([CH:17]=[CH:16][C:14]([OH:15])=[CH:13][CH:12]=1)[OH:11].[OH-].[K+].Cl>O.CS(C)=O>[Cl:8][C:7]1[C:2]([O:11][C:10]2[CH:17]=[CH:16][C:14]([OH:15])=[CH:13][CH:12]=2)=[N:3][CH:4]=[C:5]([Cl:9])[CH:6]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 785HydroquinoneHCID 14797Potassium HydroxideHCID 27666Pyridine, 2,3,5-trichloro-

생성물 1

HCID 6208804-(3,5-Dichloro-pyridin-2-yloxy)-phenol

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

실험 절차

A mixture of 2,3,5-trichloropyridine (2.5 g, 13.7 mm), hydroquinone (3.02 g, 27.4 mm), KOH (3.07 g, 54.8 mm) and DMSO (10 ml) is heated to 160° for 3 hours. The mixture is poured into water, acidified with dilute HCl and extracted with ether. The ethereal solution is washed, dried and evaporated to dryness. The crude product is chromatographed on silica gel to give crystalline 4-(3,5-dichloropyridyloxy)phenol.

후처리

  1. temperatureis heated to 160° for 3 hours
  2. extractionextracted with ether
  3. washThe ethereal solution is washed
  4. customdried
  5. customevaporated to dryness
  6. customThe crude product is chromatographed on silica gel

출처 및 근거

ORD 기록
ord-4f564ecb133e48fe8515d942dea3c6d6
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04529438

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