Cyanoacetamide → Dpn 205-734

HRID 371317노트

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HRID 371317 반응식
[C:1]([CH2:3][C:4]([NH2:6])=[O:5])#[N:2].[Na].CN(C)[CH:10]=[C:11]([C:15]1[CH:20]=[CH:19][C:18]([C:21]#[N:22])=[CH:17][CH:16]=1)[C:12](=O)[CH3:13]>C(O)C>[C:21]([C:18]1[CH:19]=[CH:20][C:15]([C:11]2[CH:10]=[C:3]([C:1]#[N:2])[C:4](=[O:5])[NH:6][C:12]=2[CH3:13])=[CH:16][CH:17]=1)#[N:22]

참가 물질

5

반응물 3

HCID 7898CyanoacetamideHCID 5360545Sodium2회HCID 542472714-[1-(Dimethylamino)-3-oxobut-1-en-2-yl]benzonitrile

생성물 1

HCID 145915Dpn 205-734

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

6.2 g of cyanacetamide are added to a freshly prepared solution of 1.14 g sodium in 200 ml of absolute ethanol. 10.6 g 4-dimethylamino-3-(4-cyanophenyl)-3-buten-2-one are added and the solution is stirred 5 hours at boiling temperature, whereby the sodium salt of the title compound soon begins to crystallize out. The mixture is allowed to cool, the crystalline product is filtered and washed with ethanol and ether (m.p. of the sodium salt>300°) (m.p. of the free form>300°).

출처 및 근거

ORD 기록
ord-04f35d4ba1034a6c8a0255f24c217fb5
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04530842

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