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O-Xylene → 3-Benzoyl-1-(2-methoxyethyl)-4-phenyl-1,3-dihydro-2H-imidazol-2-one

HRID 371775
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반응식

HRID 371775 반응식
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[NH:7][C:6]1=[O:16].C(N(CC)CC)C.[C:24](Cl)(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.C1(C)C(C)=CC=CC=1>C(Cl)(Cl)Cl>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:7]([C:24](=[O:31])[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:6]1=[O:16]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 7237O-XyleneHCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 12803422HCID 12803422, 화합물

생성물 1

HCID 128034393-Benzoyl-1-(2-methoxyethyl)-4-phenyl-1,3-dihydro-2H-imidazol-2-one

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Approximately 4.36 g. of 1-(2-methoxyethyl)-4-phenyl-4-imidazolin-2-one, 3 g. of triethylamine and 3 g. of benzoyl chloride are refluxed together for three hours in chloroform. The solution is cooled, washed with water, dried and the solvent removed to give an oil which is the O-benzoyl ester. The ester is refluxed for three hours in 20 ml. of xylene. The xylene is removed at reduced pressure. Recrystallization from ether gives the title compound as a pale yellow solid; m.p. 112°-117° C.

후처리

  1. temperatureThe solution is cooled
  2. washwashed with water
  3. customdried
  4. customthe solvent removed
  5. customto give an oil which
  6. customThe xylene is removed at reduced pressure
  7. customRecrystallization from ether

출처 및 근거

ORD 기록
ord-bd7e239373f74e8fbded034be7eef0f9
출처 데이터셋
uspto-grants-1978_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04087611

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