Sodium Hydroxide → 2-(1-Methyl-4-imidazolyl)ethylguanidine sulphate

HRID 372010

반응식

HRID 372010 반응식
[S:1]([O-:5])([O-:4])(=[O:3])=[O:2].CS[C:8]([NH2:10])=[NH2+:9].CSC(N)=[NH2+].Cl.Cl.[CH3:18][N:19]1[CH:23]=[C:22]([CH2:24][CH2:25][NH2:26])[N:21]=[CH:20]1.[OH-].[Na+]>O>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[CH3:18][N:19]1[CH:23]=[C:22]([CH2:24][CH2:25][NH:26][C:8]([NH2:10])=[NH:9])[N:21]=[CH:20]1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 6604939S-methyl isothiourea hemisulfateHCID 119576011-Methylhistamine dihydrochloride

생성물 1

HCID 1784812702-(1-Methyl-4-imidazolyl)ethylguanidine sulphate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

An aqueous solution of S-methylthiouronium sulphate (2.1 g) is added to a solution prepared from 1-methyl-4-(2-aminoethyl)imidazole dihydrochloride (3.0 g) and sodium hydroxide (1.21 g) in water. The resultant solution is heated under reflux for 17 hours. The product, isolated in a manner similar to that described in Example 1 is recrystallized from aqueous ethanol yielding pure 2-(1-methyl-4-imidazolyl)ethylguanidine sulphate, m.p. 280°-282° C.

후처리

  1. temperatureunder reflux for 17 hours
  2. customThe product, isolated in a manner similar to
  3. customis recrystallized from aqueous ethanol yielding pure 2-(1-methyl-4-imidazolyl)ethylguanidine sulphate, m.p. 280°-282° C.

출처 및 근거

ORD 기록
ord-ab8156ea395f48b1abfaeb368f94d37e
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04088769

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