Benzenepropanal → 2-(2-Phenylethyl)oxirane

HRID 372085

반응식

HRID 372085 반응식
[I-].[CH3:2][S+](C)(C)=O.[H-].[Na+].[H][H].[C:11]1([CH2:17][CH2:18][CH:19]=[O:20])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>CS(C)=O.O.C(OCC)(=O)C>[O:20]1[CH:19]([CH2:18][CH2:17][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:2]1

참가 물질

8

반응물 4

HCID 7707BenzenepropanalHCID 24758Sodium hydrideHCID 74498Sulfoxonium, trimethyl-, iodide (1:1)HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 1359552-(2-Phenylethyl)oxirane

시약·촉매·용매 3

HCID 679Dimethyl Sulfoxide용매2회HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

A solution of trimethyloxosulphonium iodide (2.64 g.) in dry dimethylsulphoxide (50 ml.) is stirred at 50°-60° C. in an atmosphere of nitrogen and an 80% w/w mineral oil dispersion of sodium hydride (0.36 g.) is added. Stirring and heating are continued until the solution is clear and no more hydrogen is evolved. A solution of 3-phenylpropionaldehyde (1.34 g.) in dry dimethyl sulphoxide (10 ml.) is added and the mixture is stirred at 50°-60° C. in an atmosphere of nitrogen for 3 hours. The mixture is cooled and diluted with water (200 ml.), and the product is obtained by extraction with ethyl acetate (3 × 80 ml.). Removal of the solvent from the combined extracts gives 1,2-epoxy-4-phenylbutane as an oil which is not further purified.

후처리

  1. temperatureheating
  2. stirringthe mixture is stirred at 50°-60° C. in an atmosphere of nitrogen for 3 hours
  3. temperatureThe mixture is cooled
  4. customRemoval of the solvent from the combined extracts

출처 및 근거

ORD 기록
ord-21c9243e88074b5e9e017892ae3176f7
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04088814

연결된 노트

불러오는 중…