(+-)-2-Butanol → HCID 12783677, 화합물

HRID 372674노트

반응식

HRID 372674 반응식
[Na].Cl[C:3]1[NH:8][C:7](=[O:9])[C:6]([F:10])=[CH:5][N:4]=1.[CH:11]([OH:15])([CH2:13][CH3:14])[CH3:12]>>[CH:11]([O:15][C:3]1[NH:8][C:7](=[O:9])[C:6]([F:10])=[CH:5][N:4]=1)([CH2:13][CH3:14])[CH3:12]

참가 물질

4

반응물 3

HCID 6568(+-)-2-ButanolHCID 2553942-Chloro-5-fluoropyrimidin-4-olHCID 5360545Sodium

생성물 1

HCID 12783677HCID 12783677, 화합물수율 91.4%

실험 절차

A 300 ml quantity of absolute sec-butanol, 5.8 g of metal sodium and 14.9 g of 2-chloro-5-fluoropyrimidin-4-one are treated in the same manner as in Example 6 to obtain crystals, which are then recrystallized from a water-ethanol mixture to give 17.0 g of white crystalline 2-sec-butoxy-5-fluoropyrimidin-4-one in a yield of 91.4%, m.p. 104°-105° C.

후처리

  1. customto obtain crystals, which
  2. customare then recrystallized from a water-ethanol mixture

출처 및 근거

ORD 기록
ord-ae6d5fe4d5744678bc8b9bfb8c08b3be
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04092313

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