Hydrazinecarboxylic acid, ethyl ester → Ethyl 3-[6-(p-bromophenyl)-3-pyridazinyl]carbazate

HRID 372694

반응식

HRID 372694 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[N:12][C:11](Cl)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[C:15]([O:19][CH2:20][CH3:21])(=[O:18])[NH:16][NH2:17]>C(O)CCC>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[N:12][C:11]([NH:17][NH:16][C:15]([O:19][CH2:20][CH3:21])=[O:18])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 64052553-(4-Bromophenyl)-6-chloropyridazine

생성물 1

HCID 20326482Ethyl 3-[6-(p-bromophenyl)-3-pyridazinyl]carbazate

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

A mixture of 2.69 g. of 6-(p-bromophenyl)-3-chloropyridazine and 3.12 g. of ethyl carbazate in 50 ml. of n-butyl alcohol is prepared. This solution is stirred and heated at reflux temperature for 4 hours. The reaction mixture is cooled to room temperature and the solvent removed on a rotation evaporator. The residue is triturated with water and the resulting solid collected by filtration. The product is recrystallized from ethanol to give crystalline material, m.p. 190°-192° C.

후처리

  1. additionA mixture of 2.69 g
  2. temperatureheated
  3. temperatureat reflux temperature for 4 hours
  4. customthe solvent removed on a rotation evaporator
  5. customThe residue is triturated with water
  6. filtrationthe resulting solid collected by filtration
  7. customThe product is recrystallized from ethanol
  8. customto give crystalline material, m.p. 190°-192° C.

출처 및 근거

ORD 기록
ord-48210dcb644945bca88c6914036e7559
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04092311

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