Benzyl Chloride → N,N-Dimethyl-N-(2-benzoylaminoethyl)benzylammonium Chloride

HRID 372939

반응식

HRID 372939 반응식
[CH3:1][N:2]([CH3:14])[CH2:3][CH2:4][NH:5][C:6](=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[Cl:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(#N)C>[Cl-:15].[CH3:1][N+:2]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([CH3:14])[CH2:3][CH2:4][NH:5][C:6](=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 7503Benzyl ChlorideHCID 113158N-(2-(Dimethylamino)ethyl)benzamide

생성물 1

HCID 19811098N,N-Dimethyl-N-(2-benzoylaminoethyl)benzylammonium Chloride

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 19.23 grams (0.10 mol) of the N-(2-dimethylaminoethyl)benzamide, prepared as described in Example 1, 12.66 grams (0.10 mol) of α-chlorotoluene and 64 milliters of acetonitrile was heated at reflux for 19.75 hours. Solid crystallized on cooling which was collected, washed with acetonitrile and dried. The yield of product was 24.0 grams (75.27% of theory); mp=175°-176° C.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 19.75 hours
  3. customSolid crystallized
  4. temperatureon cooling which
  5. customwas collected
  6. washwashed with acetonitrile
  7. customdried

출처 및 근거

ORD 기록
ord-80630acfb6e64d19be126317e4c1d130
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05162188

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