Phenol → Methyl 3-(phenyl-methoxyphosphinyl)-2-chloropropionate

HRID 374246

반응식

[C:1]1([P:7](=[O:12])([O:10][CH3:11])OC)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:13][C:14](=[CH2:19])[C:15]([O:17][CH3:18])=[O:16].C1(O)C=CC=CC=1>>[C:1]1([P:7]([O:10][CH3:11])([CH2:19][CH:14]([Cl:13])[C:15]([O:17][CH3:18])=[O:16])=[O:12])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

반응물 3

HCID 996Phenol

HCID 6659Methyl 2-chloroacrylate

HCID 75234Phosphonic acid, phenyl-, dimethyl ester

생성물 1

HCID 15052091Methyl 3-(phenyl-methoxyphosphinyl)-2-chloropropionate수율 90.1%

실험 절차

138 g of dimethyl phenylphosphonate are slowly added at 20° C. under nitrogen to a solution of 120.5 g of methyl 2-chloroacrylate and 94 g of phenol. After a reaction time of 3 hours at 70° C. phenetole is removed by vacuum distillation. The residue represents 267 g of crude product with a 93.0% purity, which corresponds to a theoretical yield of 90.1%.

후처리

customAfter a reaction time of 3 hours at 70° C. phenetole is removed by vacuum distillation

출처 및 근거

ORD 기록: ord-3307f53977b44fc8a76ecf241fbf580d
출처 데이터셋: uspto-grants-1992_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05166385

연결된 노트

불러오는 중…