2-Methyl-2-nitro-1,3-propanediol → 5-Methyl-5-nitro-1,3-dioxan-2-one

HRID 374865

반응식

HRID 374865 반응식
[CH3:1][C:2]([N+:7]([O-:9])=[O:8])([CH2:5][OH:6])[CH2:3][OH:4].[C:10]1(=O)OCC[O:11]1>C(OCC)(=O)C>[CH3:1][C:2]1([N+:7]([O-:9])=[O:8])[CH2:5][O:6][C:10](=[O:11])[O:4][CH2:3]1

참가 물질

4

반응물 2

HCID 64802-Methyl-2-nitro-1,3-propanediolHCID 7303Ethylene carbonate

생성물 1

HCID 189960545-Methyl-5-nitro-1,3-dioxan-2-one

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A solution of 2-methyl-2-nitro-1,3-propanediol and ethylene carbonate is heated overnight. The reaction mixture is diluted with ethyl acetate and the solution is washed with water. The organic phase is dried and concentrated to obtain 5-methyl-5-nitro-1,3-dioxan-2-one. This is dissolved in methanol and hydrogenated under pressure to give the 5amino compound which is acylated with dodecanoyl chloride to give the product.

후처리

  1. washthe solution is washed with water
  2. customThe organic phase is dried
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-95f89e8157fe4d36923e6412f8b53d05
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05482965

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