N-bromobutanimide → HCID 18993184, 화합물

HRID 375633노트

반응식

HRID 375633 반응식
[Br:1]N1C(=O)CCC1=O.[CH3:9][C:10]1[S:14][C:13]([CH2:15][C:16]([OH:18])=[O:17])=[CH:12][CH:11]=1>Cl(O)(=O)(=O)=O>[Br:1][CH2:9][C:10]1[S:14][C:13]([CH2:15][C:16]([OH:18])=[O:17])=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 45271772-(5-methylthiophen-2-yl)acetic Acid

생성물 1

HCID 18993184HCID 18993184, 화합물수율 82%

시약·촉매·용매 1

HCID 24247Perchloric Acid촉매

실험 절차

To a solution of N-bromosuccinimide (5.94 g, 33 mmol) in hexanes (16 mL) was added 5-methyl-2-carboxymethylthiophene (5.0 g, 32 mmol), prepared as in step 1, followed by 1 drop of perchloric acid. The reaction mixture was stirred for 22 hours at ambinet temperature and then partitioned between ethyl acetate and saturated aqueous HaHSO3 solution. The organic phase was dried over Na2SO4, filtered, and concentrated in vacuo to give 6.17 g of 5-bromomethyl-2-carboxymethylthiophene as a yellow oil.

후처리

  1. custompartitioned between ethyl acetate and saturated aqueous HaHSO3 solution
  2. dry with materialThe organic phase was dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-9a72a969e1c843cc89a85ea9a4cb1c47
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05486525

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