5-Azidomethyl-2-carboxyethylfuran → 5-Aminomethyl-2-carboxyethylfuran

HRID 375636

반응식

HRID 375636 반응식
[N:1]([CH2:4][C:5]1[O:9][C:8]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:7][CH:6]=1)=[N+]=[N-]>C(O)C.[Ni]>[NH2:1][CH2:4][C:5]1[O:9][C:8]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:7][CH:6]=1

참가 물질

4

반응물 1

HCID 189933065-Azidomethyl-2-carboxyethylfuran

생성물 1

HCID 189931745-Aminomethyl-2-carboxyethylfuran수율 98.5%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

Treatment of a solution in ethanol (50 mL) at ambient temperature of 5-azidomethyl-2-carboxyethylfuran (585 mg, 3.00 mmol), prepared as in step 3, with Raney nickel 2800 and 4 atmospheres of H2 for 24 hours, followed by filtration of the reaction mixture and concentration in vacuo gave 5-aminomethyl-2-carboxyethylfuran (0.50 g) as a yellow oil.

후처리

  1. filtrationfollowed by filtration of the reaction mixture and concentration in vacuo

출처 및 근거

ORD 기록
ord-6f66f430e4d846f59b020b67e134241f
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05486525

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