Water → 3-(1H-Indol-7-YL)propanenitrile

HRID 375683

반응식

HRID 375683 반응식
[CH3:1][C:2]1[C:3]([N+:12]([O-])=O)=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5](OC)=O.[CH3:15]OC(OC)N(C)C.[NH:23]1CCC[CH2:25][CH2:24]1.O>CN(C)C=O>[C:24]([CH2:25][CH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:4]2[C:3]=1[NH:12][CH:15]=[CH:5]2)#[N:23]

참가 물질

6

반응물 4

HCID 962WaterHCID 8082PiperidineHCID 78373Dimethylformamide dimethyl acetalHCID 79621Benzoic acid, 3-methyl-2-nitro-, methyl ester

생성물 1

HCID 199591053-(1H-Indol-7-YL)propanenitrile

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of methyl 3-methyl-2-nitrobenzoate (43 g, 0.22 mole), dimethylformamide dimethyl acetal (52.5 g, 0.44 mole) and piperidine (18.7 g, 0.22 mole) in dimethylformamide (120 ml) is heated under reflux for 24 hours, cooled and poured into water to give the crude product.

후처리

  1. temperatureunder reflux for 24 hours
  2. temperaturecooled

출처 및 근거

ORD 기록
ord-99b69e106a784f89aab343a351df0e89
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05486612

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