반응식
Cl[C:2]1[C:7]([N+:8]([O-])=O)=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[CH2:12]([N:14]([CH2:25][CH3:26])[CH2:15][CH2:16][NH:17]CC1C=CC=CC=1)[CH3:13].[CH2:27]([C:29]1[N:30]=[CH:31][NH:32][CH:33]=1)[CH3:28].[Sn](Cl)Cl.[C:37](N1C=CN=C1)(N1C=CN=C1)=[O:38].Cl>>[CH2:27]([C:29]1[N:30]=[C:31]2[N:32]([CH:33]=1)[C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:17][CH2:16][CH2:15][N:14]([CH2:12][CH3:13])[CH2:25][CH3:26])[C:7]=1[NH:8][C:37]2=[O:38])[CH3:28]참가 물질
7
실험 절차
Prepared by reaction of 4,6-dichloro-5-nitropyrimidine with N,N-diethyl-N'-benzylethylenediamine, followed by displacement with 4-ethylimidazole, reduction with tin (II) chloride, cyclization with carbonyidiimidazole and debenzylation with 6 N HCl.
출처 및 근거
- ORD 기록
- ord-b993a095a3d545f780eed3380a8ee346
- 출처 데이터셋
- uspto-grants-2000_02
- 특허 번호
- US06025489
연결된 노트
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