반응식
Cl[C:2]1[C:7]([N+:8]([O-])=O)=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[CH2:12]([N:14]([CH2:25][CH3:26])[CH2:15][CH2:16][NH:17]CC1C=CC=CC=1)[CH3:13].C([N:46]1[CH:50]=[C:49]([CH2:51][CH3:52])[N:48]=[CH:47]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Sn](Cl)Cl.[C:56](N1C=CN=C1)(N1C=CN=C1)=[O:57].Cl>>[CH2:51]([C:49]1[N:48]2[C:47]([C:56](=[O:57])[NH:8][C:7]3[C:2]([NH:17][CH2:16][CH2:15][N:14]([CH2:12][CH3:13])[CH2:25][CH3:26])=[N:3][CH:4]=[N:5][C:6]=32)=[N:46][CH:50]=1)[CH3:52]참가 물질
7
실험 절차
Prepared by reaction of 4,6-dichloro-5-nitropyrimidine with N,N-diethyl-N'-benzylethylenediamine, followed by displacement with 1-trityl-4-ethylimidazole, reduction with tin (II) chloride, cyclization with carbonyidiimidazole and deprotection with 6 N HCl.
출처 및 근거
- ORD 기록
- ord-4e71940038c641e1a4727ef946df8816
- 출처 데이터셋
- uspto-grants-2000_02
- 특허 번호
- US06025489
연결된 노트
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