Hydrazine hydrate (1:1) → 6-hydrazino-1-isobutyl-3-methyl-2,4(1H,3H)-pyrimidinedione

HRID 377613

반응식

HRID 377613 반응식
O.[NH2:2][NH2:3].Cl[C:5]1[N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:9](=[O:15])[N:8]([CH3:16])[C:7](=[O:17])[CH:6]=1>C(O)C>[NH:2]([C:5]1[N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:9](=[O:15])[N:8]([CH3:16])[C:7](=[O:17])[CH:6]=1)[NH2:3]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 52825666-Chloro-1-isobutyl-3-methylpyrimidine-2,4(1H,3H)-dione

생성물 1

HCID 193560846-hydrazino-1-isobutyl-3-methyl-2,4(1H,3H)-pyrimidinedione

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Hydrazine hydrate (6.5 ml) was added to a solution of 6-chloro-3-methyl-1-(2-methylpropyl)pyrimidine-2,4[1H,3H]-dione (10.0 g) in ethanol (40 ml). The mixture was heated at reflux for 5 hours, cooled to room temperature and then evaporated under reduced pressure. The residue was recrystallised from ethanol to give the subtitle compound (8.8 g).

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 5 hours
  3. customevaporated under reduced pressure
  4. customThe residue was recrystallised from ethanol

출처 및 근거

ORD 기록
ord-0babe5e48b794874b958f26057a9078b
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028074

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