Hydrochloric Acid → 3,5-Dibromobenzaldehyde

HRID 378163

반응식

HRID 378163 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Br:10])[CH:9]=1)[CH2:5]Br.C1N2CN3CN(C2)CN1C3.Cl.[OH2:22]>C(O)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Br:10])[CH:9]=1)[CH:5]=[O:22]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962Water2회HCID 4101HexamethylenetetramineHCID 1434273,5-Dibromobenzyl bromide

생성물 1

HCID 6220773,5-Dibromobenzaldehyde

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To 3,5-dibromobenzylbromide (Lancaster) (20 g, 0.061 mole) in H2O (27 mL) and glacial acetic acid (27 mL) was added hexamethylenetetramine (Aldrich). The reaction mixture was heated at reflux for 2 hours. Concentrated HCl (22 mL) was then added and the refluxing was continued for 30 minutes. After cooling to room temperature, the reaction mixture was poured into H2O (230 mL) and stirred for 10 minutes. The resulting precipitate was filtered, washed with H2O and dried to yield 3,5-dibromobenzaldehyde (11.45 g) as a white solid. MS and NMR were consistent with the desired structure.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 2 hours
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with H2O
  5. customdried

출처 및 근거

ORD 기록
ord-f3c898486bb044c3a3b6b92432ed6315
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028223

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