3-Bromopropionic acid → 3-(2,5-Dimethyl-phenylsulfanyl)-propionic acid

HRID 378807노트

반응식

HRID 378807 반응식
[OH-].[Na+].[CH3:3][C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:5]=1[SH:11].Br[CH2:13][CH2:14][C:15]([OH:17])=[O:16]>O>[CH3:3][C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:5]=1[S:11][CH2:13][CH2:14][C:15]([OH:17])=[O:16]

참가 물질

5

반응물 3

HCID 115533-Bromopropionic acidHCID 14798Sodium HydroxideHCID 776152,5-Xylenethiol

생성물 1

HCID 167883143-(2,5-Dimethyl-phenylsulfanyl)-propionic acid

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
10 °C

실험 절차

90 g (2.25 mol) of sodium hydroxide were dissolved in 500 ml of water and, with cooling at 10° C., admixed with 147.59 g of 2,5-dimethylthiophenol. Cooling was continued and 180.1 g (1.18 mol) of 3-bromopropionic acid were added below 25° C. The mixture was stirred for another 4 h at room temperature and then washed with diethyl ether (3×500 ml). The aqueous solution was made acidic using 1M HCl, and the precipitated product was filtered off and washed with water.

후처리

  1. temperatureCooling
  2. washwashed with diethyl ether (3×500 ml)
  3. filtrationthe precipitated product was filtered off
  4. washwashed with water

출처 및 근거

ORD 기록
ord-a6381f356a23444b9c61ffa6e2b89451
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06297196B1

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