Hydrochloric Acid → 3-(Benzyloxy)benzoic acid

HRID 380126

반응식

HRID 380126 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([O:14]C)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>COCCOC>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([OH:14])=[O:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13368031Methyl 3-(benzyloxy)benzoate

생성물 1

HCID 3092263-(Benzyloxy)benzoic acid수율 97.7%

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

A solution of methyl 3-benzyloxybenzoate (38.0 g) and 5N NaOH solution (207 ml) in 1,2-dimethoxyethane (207 ml) was stirred at room temperature for 3 hours 30 minutes and at 100° C. for 1 hour 20 minutes. The reaction mixture was cooled with ice water, mixed with 6N HCl (1.1 mole), and extracted with diethyl ether. The extract was washed with brine, dried over MgSO4, and evaporated in vacuo to afford 3-benzyloxybenzoic acid (34.96 g) as a colorless powder.

후처리

  1. extractionextracted with diethyl ether
  2. washThe extract was washed with brine
  3. dry with materialdried over MgSO4
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-d8ec4d9da1df4d6e84697fca93065a3d
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06300344B1

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