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Hydrochloric Acid → 6-[1-(3-Nitro-2-pyridyl)piperazin-4-yl-carbonyl]nicotinic acid

HRID 381350
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HRID 381350 반응식
C[O:2][C:3](=[O:27])[C:4]1[CH:9]=[CH:8][C:7]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([N+:24]([O-:26])=[O:25])=[CH:22][CH:21]=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[N:6][CH:5]=1.Cl.O>CO.[OH-].[Na+]>[N+:24]([C:23]1[C:18]([N:15]2[CH2:16][CH2:17][N:12]([C:10]([C:7]3[CH:8]=[CH:9][C:4]([C:3]([OH:27])=[O:2])=[CH:5][N:6]=3)=[O:11])[CH2:13][CH2:14]2)=[N:19][CH:20]=[CH:21][CH:22]=1)([O-:26])=[O:25]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 108616096-[1-(3-Nitro-2-pyridyl)piperazin-4-yl-carbonyl]nicotinic acid methyl ester

생성물 1

HCID 183628396-[1-(3-Nitro-2-pyridyl)piperazin-4-yl-carbonyl]nicotinic acid수율 90%

시약·촉매·용매 2

HCID 887Methanol용매
HCID 14798
Sodium Hydroxide
용매

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온도
30 °C

실험 절차

6-[1-(3-Nitro-2-pyridyl)piperazin-4-yl-carbonyl]nicotinic acid methyl ester (10 g) was dissolved in methanol (75 ml) and with the addition of aqueous 1N-sodium hydroxide (75 ml), the mixture was stirred at 30° C for 2 hours. With the slow addition of 3N-hydrochloric acid for neutralization (pH=˜5), water (110 ml) was slowly added to the mixture for precipitate. After 2-hours stirring, the precipitate was filtered, washed with water and dried to give a desired compound of 8.66 g (yield: 90%).

후처리

  1. additionwas slowly added to the mixture for precipitate
  2. stirringAfter 2-hours stirring
  3. filtrationthe precipitate was filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-12e2f0dfc3034e42ba1af00a243703dd
출처 데이터셋
uspto-grants-2001_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06306860B1

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