1-Bromo-3-chloropropane → 1-Phenethyl-4-(3-chloropropyl)piperazine dihydrochloride

HRID 3815

반응식

HRID 3815 반응식
[CH2:1]([N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1)[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[OH-].[K+].Br[CH2:18][CH2:19][CH2:20][Cl:21]>CS(C)=O>[ClH:21].[ClH:21].[CH2:1]([N:9]1[CH2:10][CH2:11][N:12]([CH2:18][CH2:19][CH2:20][Cl:21])[CH2:13][CH2:14]1)[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 80061-Bromo-3-chloropropaneHCID 14797Potassium HydroxideHCID 792141-Phenethylpiperazine

생성물 1

HCID 201531791-Phenethyl-4-(3-chloropropyl)piperazine dihydrochloride수율 188.8%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

The procedure described in Example 1(a) was followed, using 29.4 g of 1-phenethyl piperazine, 25.0 g of potassium hydroxide, 100 ml of dimethyl sulfoxide and 24.0 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 32.6 g (64% of theory) of 1-phenethyl-4-(3-chloropropyl)piperazine dihydrochloride as an off-white crystalline solid.

출처 및 근거

ORD 기록
ord-4cbd87311b894e64af3aedbc4e278737
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04722926

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