1-Bromo-3-chloropropane → 1-Phenethyl-4-(3-chloropropyl)piperazine dihydrochloride
반응식
[CH2:1]([N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1)[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[OH-].[K+].Br[CH2:18][CH2:19][CH2:20][Cl:21]>CS(C)=O>[ClH:21].[ClH:21].[CH2:1]([N:9]1[CH2:10][CH2:11][N:12]([CH2:18][CH2:19][CH2:20][Cl:21])[CH2:13][CH2:14]1)[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1참가 물질
5
실험 절차
The procedure described in Example 1(a) was followed, using 29.4 g of 1-phenethyl piperazine, 25.0 g of potassium hydroxide, 100 ml of dimethyl sulfoxide and 24.0 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 32.6 g (64% of theory) of 1-phenethyl-4-(3-chloropropyl)piperazine dihydrochloride as an off-white crystalline solid.
출처 및 근거
- ORD 기록
- ord-4cbd87311b894e64af3aedbc4e278737
- 출처 데이터셋
- uspto-grants-1988_02
- 특허 번호
- US04722926
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