Ethyl 4,4,4-trifluoroacetoacetate → Ethyl 4,4,4-trifluoro-3-hydroxybutanoate

HRID 381799

반응식

HRID 381799 반응식
[F:1][C:2]([F:12])([F:11])[C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[H][H]>[Pt].C(N(CC)CC)C>[F:1][C:2]([F:11])([F:12])[CH:3]([OH:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6]

참가 물질

5

반응물 2

HCID 67793Ethyl 4,4,4-trifluoroacetoacetateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 136210Ethyl 4,4,4-trifluoro-3-hydroxybutanoate수율 96%

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 8471Triethylamine용매

반응 조건

온도
40 °C

실험 절차

Ethyl 4,4,4-trifluoroacetoacetate (50 g), under a blanket of nitrogen gas, is heated to 40° C. and treated with platinum (0.5 g of 1% Pt/C, 0.05% load) and triethylamine (0.2 g, 0.4% load). Hydrogen is charged to a pressure of 5 bars, and the mixture agitated at 40° C. for 6h. After filtration to remove the catalyst, 48.5 g (96% yield) of ethyl 4,4,4-trifluoro-3-hydroxybutyrate is obtained.

후처리

  1. filtrationAfter filtration
  2. customto remove the catalyst

출처 및 근거

ORD 기록
ord-b07d5a3524ed43d681a9c5a766d9df0e
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06307094B1

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