1-Bromo-3-chloropropane → 1-(4-Chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride

HRID 3818

반응식

HRID 3818 반응식
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[OH-].[K+].Br[CH2:19][CH2:20][CH2:21][Cl:22]>CS(C)=O>[ClH:1].[ClH:22].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][N:11]([CH2:19][CH2:20][CH2:21][Cl:22])[CH2:10][CH2:9]2)=[CH:14][CH:15]=1

참가 물질

5

반응물 3

HCID 80061-Bromo-3-chloropropaneHCID 14797Potassium HydroxideHCID 122357141-[2-(4-Chlorophenyl)ethyl]piperazine

생성물 1

HCID 201531821-(4-Chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride수율 118.3%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

The procedure described in Example 17(a) was followed, using 6.5 g of 1-(4-chlorophenethyl)piperazine, 6.0 g of potassium hydroxide, 125 ml of dimethyl sulfoxide and 4.6 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 6.4 g (59% of theory) of 1-(4-chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.

출처 및 근거

ORD 기록
ord-3718907b4bb04353b2d6e7ee3e40a47d
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04722926

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