Dimethylformamide dimethyl acetal → (E)-ethyl 2-((dimethylamino)methylene)-3-oxopentanoate

HRID 38236

반응식

HRID 38236 반응식
[O:1]=[C:2]([CH2:9][CH3:10])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].CO[CH:13](OC)[N:14]([CH3:16])[CH3:15]>CN(C=O)C>[CH3:13][N:14](/[CH:16]=[C:3](\[C:2](=[O:1])[CH2:9][CH3:10])/[C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH3:15]

참가 물질

4

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 78656Ethyl 3-oxovalerate

생성물 1

HCID 11820077(E)-ethyl 2-((dimethylamino)methylene)-3-oxopentanoate수율 100%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

According to Scheme 9 Step 1: A solution of ethyl 3-oxopentanoate (13.9 mmol, 2.00 g) and of 1,1-dimethoxy-N,N-dimethylmethanamine (13.9 mmole, 1.84 mL) in DMF (10 mL) was microwaved for 30 min at 120° C. After evaporation of the solvent, 2.76 g (13.9 mmol) of (E)-ethyl 2-((dimethylamino)methylene)-3-oxopentanoate were obtained and used without further purification.

후처리

  1. customAfter evaporation of the solvent

출처 및 근거

ORD 기록
ord-36ed30f54e374bdc94cf8a2fd6430b5a
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524718B2

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