1-Bromo-3-chloropropane → 1-(3-Phenylpropyl)-4-(3-chloropropyl)piperazine dihydrochloride

HRID 3824

반응식

HRID 3824 반응식
[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].Br[CH2:19][CH2:20][CH2:21][Cl:22]>CS(C)=O>[ClH:22].[ClH:22].[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:11][CH2:12][N:13]([CH2:19][CH2:20][CH2:21][Cl:22])[CH2:14][CH2:15]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 80061-Bromo-3-chloropropaneHCID 14797Potassium HydroxideHCID 7965341-(3-Phenylpropyl)piperazine

생성물 1

HCID 201531841-(3-Phenylpropyl)-4-(3-chloropropyl)piperazine dihydrochloride수율 219.3%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

The procedure described in Example 17(a) was followed, using 36.0 g of (3-phenylpropyl)piperazine, 25.0 g of potassium hydroxide, 125 ml of dimethyl sulfoxide and 28.0 g of 1-bromo-3-chloropropane, to give 46.0 g (73% of theory) of 1-(3-phenylpropyl)-4-(3-chloropropyl)piperazine dihydrochloride.

출처 및 근거

ORD 기록
ord-249a67ffce174364b0ae5c54cd4ac01c
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04722926

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