Hydrochloric Acid → (E)-1-(4-Methylpyrid-2-yl)-2-styryl-1H-benzimidazole hydrochloride

HRID 382515

반응식

HRID 382515 반응식
[CH:1]([C:9]1[NH:13][C:12]2[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=2[N:10]=1)=[CH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.F[C:19]1[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][N:20]=1.N1C=CC=CC=1N1C2C=CC=CC=2N=C1/C=C/C1C=CC=CC=1.[ClH:49]>CO>[ClH:49].[CH3:25][C:23]1[CH:22]=[CH:21][N:20]=[C:19]([N:13]2[C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[N:10]=[C:9]2/[CH:1]=[CH:2]/[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:24]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 2429652-(2-Phenylethenyl)-1h-benzimidazoleHCID 27374032-Fluoro-4-methylpyridineHCID 9796241(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole

생성물 1

HCID 22736699(E)-1-(4-Methylpyrid-2-yl)-2-styryl-1H-benzimidazole hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 2-fluoro-4-methylpyridine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was treated with a 10% methanol solution of hydrogen chloride and concentrated to dryness. The residue was recrystallized from ethyl acetate/n-hexane to give the titled compound.

후처리

  1. concentrationconcentrated to dryness
  2. customThe residue was recrystallized from ethyl acetate/n-hexane

출처 및 근거

ORD 기록
ord-b6bc70bd70dd453893ec6ad11ec32443
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06310079B1

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