Phenylacetic Acid → 2,5-Dimethyl-1-(phenylacetyl)-piperazine

HRID 38272

반응식

HRID 38272 반응식
C(N(C(C)C)CC)(C)C.[CH3:10][C@H:11]1[CH2:16][NH:15][C@H:14]([CH3:17])[CH2:13][NH:12]1.[C:18]1([CH2:24][C:25](O)=[O:26])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>CN(C=O)C.O>[CH3:10][CH:11]1[CH2:16][NH:15][CH:14]([CH3:17])[CH2:13][N:12]1[C:25](=[O:26])[CH2:24][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

7

반응물 4

HCID 999Phenylacetic AcidHCID 81531DiisopropylethylamineHCID 2206722,5-Dimethylpiperazine, trans-HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

생성물 1

HCID 649793942,5-Dimethyl-1-(phenylacetyl)-piperazine수율 178.8%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

Diisopropylethylamine (0.38 ml) was added to a solution of trans-2,5-dimethyl-piperazine (1.50 g), phenyl acetic acid (0.59 g) and HATU (1.55 g) in DMF (10 ml). The reaction mixture was stirred overnight at ambient temperature. The solution was diluted with water, then extracted with ethyl acetate. The organic extracts were dried (MgSO4) then concentrated in vacuo to give the sub-title compound (1.8 g).

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic extracts were dried (MgSO4)
  3. concentrationthen concentrated in vacuo

출처 및 근거

ORD 기록
ord-715e1f13ccc9473e8841e52835088166
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524715B2

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