Hydrochloric Acid → Ethyl dodecanoyl-3, 5-dimethylpyrrole-2-carboxylate

HRID 382821노트

반응식

HRID 382821 반응식
[Al+3].[Cl-].[Cl-].[Cl-].[CH3:5][C:6]1[CH:10]=[C:9]([CH3:11])[NH:8][C:7]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13].[C:17](Cl)(=[O:29])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28].Cl>O.ClCCl>[C:17]([C:10]1[C:6]([CH3:5])=[C:7]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:8][C:9]=1[CH3:11])(=[O:29])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 8166Dodecanoyl chlorideHCID 1374771H-Pyrrole-2-carboxylic acid, 3,5-dimethyl-, ethyl esterHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 18362055Ethyl dodecanoyl-3, 5-dimethylpyrrole-2-carboxylate

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

1.46 g (11 mmol) of AlCl3 were added to a solution of 1.67 g (10 mmol) of ethyl 3,5-dimethylpyrrole-2-carboxylate a 2.63 g (12 mmol) of dodecanoyl chloride in 30 ml of absol. Dichloromethane and then stirred for 24 h. Addition of water and dilute HCl is followed by extraction twice with CH2Cl2. The organic phases are washed with dilute NaOH, dried over Na2SO4 and concentrated. The product is recrystallized from isopropanol.

후처리

  1. extractionis followed by extraction twice with CH2Cl2
  2. washThe organic phases are washed with dilute NaOH
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated
  5. customThe product is recrystallized from isopropanol

출처 및 근거

ORD 기록
ord-85823facb44a4b2297b82673efd223d8
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06310217B1

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