Stearic Acid → 1H-Indole-2-carboxylic acid, 3-(1-oxododecyl)-, ethyl ester

HRID 382827노트

반응식

HRID 382827 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([O:12][CH2:13][CH3:14])=[O:11].[C:15](O)(=[O:33])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]CCCCCC.FC(F)(F)C(OC(=O)C(F)(F)F)=O.[OH-].[Na+]>C(Cl)Cl>[C:15]([C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][C:2]=1[C:10]([O:12][CH2:13][CH3:14])=[O:11])(=[O:33])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]

참가 물질

6

반응물 4

HCID 5281Stearic AcidHCID 9845Trifluoroacetic anhydrideHCID 14798Sodium HydroxideHCID 73125Ethyl indole-2-carboxylate

생성물 1

HCID 106192401H-Indole-2-carboxylic acid, 3-(1-oxododecyl)-, ethyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 3.8 g (20 mmol) of ethyl indole-2-carboxylate, 6.0 g (30 mmol) of octadecanoic acid, 1.0 g of polyphosphoric acid, 20 ml of absol. CH2Cl2 and 4.4 ml of trifluoroacetic anhydride is stirred at room temperature for 4 h. Then 1 M NaOH is added, and the mixture is extracted with ether. The ether phase is dried over Na2SO4 and the solvent is distilled off. The product precipitates after addition of petroleum ether.

후처리

  1. extractionthe mixture is extracted with ether
  2. dry with materialThe ether phase is dried over Na2SO4
  3. distillationthe solvent is distilled off
  4. customThe product precipitates
  5. additionafter addition of petroleum ether

출처 및 근거

ORD 기록
ord-0563c47bc0a54358ac6a36e284a2ab80
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06310217B1

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