Hydrochloric Acid → Cyanomethyl-8-hydroxy-7-quinolinecarboxamide

HRID 382895노트

반응식

HRID 382895 반응식
[OH:1][C:2]1[C:3]([C:12]([OH:14])=O)=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.[NH2:15][CH2:16][C:17]#N.Cl.CC[N:22]=C=NCCCN(C)C.Cl.C1C=CC2N(O)N=NC=2C=1>CN(C)C=O.O.C(N(CC)CC)C>[C:16]([CH2:17][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[C:2]([OH:1])[C:3]([C:12]([NH2:22])=[O:14])=[CH:4][CH:5]=2)[N:10]=1)#[N:15]

참가 물질

9

반응물 5

HCID 313Hydrochloric AcidHCID 10901AminoacetonitrileHCID 757711-HydroxybenzotriazoleHCID 2313638-Hydroxyquinoline-7-carboxylic AcidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

생성물 1

HCID 86757553Cyanomethyl-8-hydroxy-7-quinolinecarboxamide

시약·촉매·용매 3

HCID 962Water용매HCID 6228Dimethylformamide용매HCID 8471Triethylamine용매

실험 절차

8-hydroxyquinoline-7-carboxylic acid (0.51 g), aminoacetonitrile.HCl (0.27 g), and triethylamine (0.38 mL) are dissolved in 10 mL dimethylformamide. EDC.HCl (0.54 g) and HOBt.H2O (0.38 g) are added and the reaction is stirred at room temperature for 2 days. The reaction is poured into 50 mL ice/H2O and stirred.

후처리

  1. stirringstirred

출처 및 근거

ORD 기록
ord-a3ecd77c8a594a2393fb04309cc1f8e3
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06310211B1

반응 노트

불러오는 중…