Methanol → 4-Oxo-4-(3-(trifluoromethyl)benzylamino)butyric acid

HRID 383982

반응식

HRID 383982 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH2:9][NH2:10])[CH:6]=[CH:7][CH:8]=1.[C:13]1(=[O:19])[O:18][C:16](=[O:17])[CH2:15][CH2:14]1.CO>CCOCC>[O:19]=[C:13]([NH:10][CH2:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:11])([F:12])[F:1])[CH:4]=1)[CH2:14][CH2:15][C:16]([OH:18])=[O:17]

참가 물질

5

반응물 3

HCID 887MethanolHCID 7922Succinic anhydrideHCID 759623-(Trifluoromethyl)benzylamine

생성물 1

HCID 433971044-Oxo-4-(3-(trifluoromethyl)benzylamino)butyric acid수율 44.2%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A solution of 15.0 g (85.6 mmol) of (3-(trifluoromethyl)phenyl)methylamine in ether (40 ml) was added dropwise to a suspension of 7.5 g (85.6 mmol) of succinic anhydride in ether (450 ml) within 30 min. The mixture was then stirred for 72 h at room temperature. The deposit obtained was filtered and dried. After column chromatography (EE/MeOH 1:1) of the residue, 10.4 g (37.8 mmol, 44%) of 4-oxo-4-(3-(trifluoromethyl)benzylamino)butyric acid were obtained.

후처리

  1. customThe deposit obtained
  2. filtrationwas filtered
  3. customdried

출처 및 근거

ORD 기록
ord-c4e7352f5de849dca980d4cce877ddc6
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367700B2

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