Carbon tetrabromide → 2-Bromo-6-(1-bromo-2-fluoroethyl)pyridine
반응식
[Br:1][C:2]1[N:7]=[C:6]([CH:8](O)[CH2:9][F:10])[CH:5]=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:32]>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([CH:8]([Br:32])[CH2:9][F:10])[N:7]=1참가 물질
5
실험 절차
1-(6-Bromopyridin-2-yl)-2-fluoroethanol (0.525 g, 2.39 mmol) and triphenylphosphine (1.252 g, 4.77 mmol) were taken up in DCM (25 mL). A solution of carbon tetrabromide (1.582 g, 4.77 mmol) in DCM (10 mL) was added and the resulting mixture stirred at room temperature overnight. The precipitate was removed by filtration and the filtrate concentrated in vacuo. Purification of the residue by silica gel column chromatography (0-10% EtOAc-hexanes) gave the title compound as a colorless oil.
후처리
- customThe precipitate was removed by filtration
- concentrationthe filtrate concentrated in vacuo
- customPurification of the residue by silica gel column chromatography (0-10% EtOAc-hexanes)
출처 및 근거
- ORD 기록
- ord-3690968ecc6f47458254116afc17fff1
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08367706B2
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