Bromoacetic Acid → [(2-Propanylideneamino)oxy]acetic acid

HRID 386119노트

반응식

HRID 386119 반응식
Br[CH2:2][C:3]([OH:5])=[O:4].[OH-].[Na+].[CH3:8][C:9](=[N:11][OH:12])[CH3:10]>>[CH3:8][C:9](=[N:11][O:12][CH2:2][C:3]([OH:5])=[O:4])[CH3:10]

참가 물질

4

반응물 3

HCID 6227Bromoacetic AcidHCID 14798Sodium Hydroxide2회HCID 67180Acetone, oxime

생성물 1

HCID 79344[(2-Propanylideneamino)oxy]acetic acid

실험 절차

To bromoacetic acid (500 g, 3.60 mol) and ice (400 g) was added dropwise 40% sodium hydroxide (375 g, 3.75 mol) at below 20° C. Acetone oxime (239 g, 3.27 mol) was added. At below 20° C., 40% sodium hydroxide (375 g, 3.27 mol) was added dropwise. The reaction mixture was allowed to warm to room temperature overnight and extracted with 500 ml of ether. The aqueous phase was acidified to pH 2 and extracted with ether (3×500 ml). The combined organic layers were dried over MgSO4, filtered, and concentrated to dryness. Hexane (250 ml) was added to the residue and the precipitate was collected to give the title compound.

후처리

  1. extractionextracted with 500 ml of ether
  2. extractionextracted with ether (3×500 ml)
  3. dry with materialThe combined organic layers were dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated to dryness
  6. additionHexane (250 ml) was added to the residue
  7. customthe precipitate was collected

출처 및 근거

ORD 기록
ord-860c3ea72f5e459b81356b064cc1d325
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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