Hydrochloric Acid → 5-azidopentanoic Acid

HRID 386422노트

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HRID 386422 반응식
[N:1]([CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O:10]CC)=[O:9])=[N+:2]=[N-:3].CN(C)C=O.[OH-].[Li+].Cl>O>[N:1]([CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9])=[N+:2]=[N-:3]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 6228DimethylformamideHCID 123821765-Azidopentanoic acid ethyl ester

생성물 1

HCID 111161715-azidopentanoic Acid수율 99%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
25 °C

실험 절차

To ethyl 5-azidovalerate (1.6 g; 10 mmol; Example 2.1) in 5 ml-dimethylformamide, was added lithium hydroxide (1.0 g; 20 mmol; Fisher) in 5 ml water, and the reaction mixture was stirred 12 h at 25° C. The reaction mixture was adjusted to pH ˜4 by addition of 1 N HCl and was extracted with 100 ml diethyl ether. The resulting organic layer was washed with water (100 ml) and brine (100 ml), dried over sodium sulfate, and dried in vacuo. Yield: 1.4 g (9.8 mmol, 99% yield).

후처리

  1. extractionwas extracted with 100 ml diethyl ether
  2. washThe resulting organic layer was washed with water (100 ml) and brine (100 ml)
  3. dry with materialdried over sodium sulfate
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-5ca6025cb0c84ab8afc1e58f3fb6d681
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372839B2

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