Acetone → 4-(3-Ethoxy-4-hydroxyphenyl)but-3-en-2-one

HRID 38667

반응식

HRID 38667 반응식
[OH-].[Na+].[CH2:3]([O:5][C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=1[OH:14])[CH:9]=O)[CH3:4].Cl.[CH3:16][C:17]([CH3:19])=[O:18]>C(O)C.O>[CH2:3]([O:5][C:6]1[CH:7]=[C:8]([CH:9]=[CH:16][C:17](=[O:18])[CH3:19])[CH:11]=[CH:12][C:13]=1[OH:14])[CH3:4]

참가 물질

7

반응물 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 8467EthylvanillinHCID 14798Sodium Hydroxide

생성물 1

HCID 692474294-(3-Ethoxy-4-hydroxyphenyl)but-3-en-2-one수율 70.4%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

10% sodium hydroxide aqueous solution (80 ml) was added under stirring to a solution of 3-ethoxy-4-hydroxybenzaldehyde (16.6 g, 100 mmol) in acetone (50 ml), 95% ethanol (50 ml) and water (400 ml). The reaction mixture was stirred for 24 hr at room temperature, after the reaction completed, the reaction mixture was neutralized with 6N hydrochloric acid to adjust pH=7.0, the precipitated yellow solid was collected by filtration, washed with water and ethanol successively, dried, and then recrystallized from 95% ethanol to give 14.5 g of a yellow crystal, mp: 98-100° C., yield 70.4%.

후처리

  1. filtrationthe precipitated yellow solid was collected by filtration
  2. washwashed with water and ethanol successively
  3. customdried
  4. customrecrystallized from 95% ethanol

출처 및 근거

ORD 기록
ord-ff7f346f666d4b05a119f33b618adecf
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524744B2

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