Hydrochloric Acid → 6-(1H-Indol-4-yl)-4-[5-(4-morpholinylmethyl)-1,3,4-oxadiazol-2-yl]-1H-indazole

HRID 38860노트

반응식

HRID 38860 반응식
[NH:1]1[C:9]2[C:4](=[C:5]([C:10]3[CH:18]=[C:17]4[C:13]([CH:14]=[N:15][N:16]4S(C4C=CC(C)=CC=4)(=O)=O)=[C:12]([C:29]4[O:30][C:31]([CH2:34][N:35]5[CH2:40][CH2:39][O:38][CH2:37][CH2:36]5)=[N:32][N:33]=4)[CH:11]=3)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[OH-].[Na+].Cl>C(O)(C)C>[NH:1]1[C:9]2[C:4](=[C:5]([C:10]3[CH:18]=[C:17]4[C:13]([CH:14]=[N:15][NH:16]4)=[C:12]([C:29]4[O:30][C:31]([CH2:34][N:35]5[CH2:40][CH2:39][O:38][CH2:37][CH2:36]5)=[N:32][N:33]=4)[CH:11]=3)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 667766026-(1H-Indol-4-yl)-1-[(4-methylphenyl)sulfonyl]-4-[5-(4-morpholinylmethyl)-1,3,4-oxadiazol-2-yl]-1H-indazole

생성물 1

HCID 468925236-(1H-Indol-4-yl)-4-[5-(4-morpholinylmethyl)-1,3,4-oxadiazol-2-yl]-1H-indazole

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A stirred solution of 6-(1H-indol-4-yl)-1-[(4-methylphenyl)sulfonyl]-4-[5-(4-morpholinylmethyl)-1,3,4-oxadiazol-2-yl]-1H-indazole (25 mg, 0.045 mmol) and 2M sodium hydroxide (3 ml) in isopropanol (10 ml) was stirred at room temperature for 1 h. The solution was treated with 2M hydrochloric acid (3 ml) and evaporated to low bulk until the product was precipitated. The resulting solid was collected by filtration and washed with water to give the title compound as a cream coloured solid (15 mg).

후처리

  1. customevaporated to low bulk until the product
  2. customwas precipitated
  3. filtrationThe resulting solid was collected by filtration
  4. washwashed with water

출처 및 근거

ORD 기록
ord-d8d28d82c6124e85afd27bf977648fe3
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524751B2

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